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Journal of Lipid Research, Vol. 13, 356-363, May 1972
Copyright © 1972 by Lipid Research, Inc.

Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma

John C. LaRosa , Robert I. Levy , Herbert G. Windmueller , and Donald S. Fredrickson

Molecular Disease Branch, National Heart and Lung Institute, Bethesda, Maryland 20014

Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue. These differences included response to inhibitors and to high density lipoprotein in the incubation media. Heparin-released triglyceride lipase from liver, when compared with that from adipose tissue, was relatively inactive against lipoprotein substrates. The triglyceride lipase from postheparin plasma exhibited properties more like those of liver. These studies raise the possibility that triglyceride lipase in postheparin plasma may be heterogeneous and that levels of the enzyme in postheparin plasma may not accurately reflect the capacity for clearance of triglyceride from the plasma.

Supplementary key words lipoprotein lipase • postheparin lipolytic activity • high density lipoprotein • liver • adipose tissue

Submitted on June 29, 1971
Accepted on December 15, 1971


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