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Journal of Lipid Research, Vol. 13, 383-389, May 1972
Copyright © 1972 by Lipid Research, Inc.

Hyperlipoproteinemia in fasting ponies

M. D. Morris , D. B. Zilversmit , and H. F. Hintz

Graduate School of Nutrition and Section of Biochemistry and Molecular Biology, Division of Biological Sciences; and Equine Research Program, Cornell University, Ithaca, New York 14850

Ponies fasted for up to 8 days showed, both by agarose electrophoresis and preparative ultracentrifugation, the appearance of a pre-ßbeta;-migrating, very low density lipoprotein fraction in plasma. This lipoprotein differs from the very low density lipoprotein found in humans and rats in that it contains a relatively smaller amount of total cholesterol, 85% of which is present in the unesterified form. By the 8th day of fasting, plasma triglyceride concentrations had increased from a prefasting level of 20 mg/dl to as high as 1000 mg/dl. The increase in plasma lipid concentrations as a result of fasting was highly variable. Accumulation of plasma cholesterol and triglyceride after injection of Triton WR 1339 was not related to the degree of fasting hyperlipidemia. This suggests that the hyperlipoproteinemia of fasting may result from an impaired utilization of very low density lipoproteins.

Supplementary key words agarose electrophoresis • ßbeta;-lipoproteins • pre-ßbeta;-lipoproteins • -lipoproteins • very low density lipoproteins • high density lipoproteins • free fatty acids • cholesterol • cholesteryl ester • triglyceride • phospholipid • Triton WR 1339

Submitted on July 29, 1971
Accepted on January 26, 1972

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