Journal of Lipid Research, Vol. 13, 571-573, September 1972
Copyright © 1972 by Lipid Research, Inc.

Diurnal variation of HMG CoA reductase activity in rat intestine

S. Shefer , S. Hauser , V. Lapar , and E. H. Mosbach

Department of Lipid Research of The Public Health Research Institute of the City of New York, Inc., and the Bureau of Laboratories, New York City Health Department, New York 10016

HMG CoA reductase activity of rat intestinal mucosa has a diurnal rhythm which coincides with the diurnal variation of the hepatic HMG CoA reductase but has a lower amplitude. The rhythmic variation of the intestinal reductase was present in both jejunal and ileal crypt cell microsomes and was not abolished by cholestyramine administration.

Supplementary key words cholestyramine • ileum • jejunum • crypt cells • liver

Submitted on March 6, 1972
Accepted on April 19, 1972

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