Journal of Lipid Research, Vol. 13, 797-801, November 1972
Copyright © 1972 by Lipid Research, Inc.

Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase

Stanley Goldfarb and Henry C. Pitot

Departments of Oncology and Pathology, The Medical School, University of Wisconsin, Madison, Wisconsin 53706

The diurnal cycle of hepatic HMG CoA reductase activity was studied under conditions of controlled feeding where the percentage of dietary lipid, alone or in combination with 2% cholestyramine, was varied. Cholestyramine caused an increase in HMG CoA reductase activity that began soon after feeding started and peaked 6 hr later. In contrast, a diet containing 20% corn oil was a much weaker inducer of the enzyme but caused a prolonged elevation that began late in the fasting part of the cycle. These patterns suggest two different mechanisms of action.

Supplementary key words hepatic cholesterogenesis • dietary corn oil • cyclic feeding • diurnal cycles • feeding patterns

Submitted on April 17, 1972
Accepted on August 3, 1972

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?