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Journal of Lipid Research, Vol. 14, 255-a-257, March 1973
Copyright © 1973 by Lipid Research, Inc.

Distribution of alamethicin in lipid membranes and water

W. S. Chelack and A. Petkau

Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada

The concentration of alamethicin in aqueous solutions was quantitated using measurements of the spot area on thin-layer chromatograms. These data were utilized to measure a partition coefficient of 17 for alamethicin in a phospholipid membrane-water system under equilibrium dialysis conditions.

Supplementary key words thin-layer chromatography • cyclopeptide antibiotic • phospholipid membranes • equilibrium dialysis • partition coefficient

Submitted on May 31, 1972
Accepted on November 7, 1972

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