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Journal of Lipid Research, Vol. 14, 415-421, July 1973
Copyright © 1973 by Lipid Research, Inc.

Regulation of triglyceride biosynthesis in adipose and intestinal tissue

Diether Polheim , J. S. K. David , F. Michael Schultz , Mary Bob Wylie , and John M. Johnston

Department of Biochemistry, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

The synthesis of phosphatidic acid and di- and triglycerides via the glycerol-3-phosphate pathway is markedly inhibited by 2-monooleyl ether in microsomal and whole cell preparations obtained from adipose and intestinal tissue. Monoglycerides are also inhibitors under conditions in which their hydrolysis is minimized. A correlation between inhibition by, and the hydrolysis of, monoglycerides has been demonstrated. 2-Monooleyl ether is the most effective inhibitor of the several mono- and di- ethers and esters studied. The specificity of the inhibition of glycerol-3-phosphate acylation by 2-monoethers or 2-monoesters has been demonstrated because microsomal NADH- and NADPH-cytochrome c reductase activities were not significantly inhibited. The reported control mechanism for triglyceride biosynthesis is discussed in relation to the regulation of fatty acid uptake and release in adipose tissue and the absorption and metabolism of triglycerides by the intestinal mucosa.

Supplementary key words monoglyceride and glycerol-3-phosphate pathways • 2-monoethers

Submitted on August 29, 1972
Revised on January 11, 1973
Accepted on March 6, 1973

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