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Journal of Lipid Research, Vol. 14, 495-503, July 1973
Copyright © 1973 by Lipid Research, Inc.

Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans

Stuart G. Gordon , Kathleen Smith , Joseph L. Rabinowitz , and P. Roy Vagelos

Departments of Biological Chemistry and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, and Veterans Administration Hospital, Philadelphia, Pennsylvania 19104

The report that sweat of certain schizophrenics contains the branched chain fatty acid, trans-3-methyl-2-hexenoic acid (TMHA), stimulated an investigation to evaluate the relationship between this fatty acid and schizophrenia. A sensitive and specific gas-liquid chromatography-mass spectroscopic procedure was developed for analyzing biological fluids for TMHA. Analysis of sweat samples from normal and schizophrenic subjects indicated that the sweat of both groups contains comparable quantities of this fatty acid. In addition, the fate of intravenously administered ¹⁴C-labeled TMHA was shown to be similar in normal and schizophrenic subjects. It is concluded that there is no relationship between TMHA and schizophrenia.

Supplementary key words short-chain fatty acids • gas-liquid chromatography-mass spectroscopy

Submitted on December 28, 1972
Accepted on March 28, 1973

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