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Journal of Lipid Research, Vol. 14, 557-562, September 1973
Copyright © 1973 by Lipid Research, Inc.

Regulation by dietary choline of hepatic fatty acid synthetase in the rat

Bruno Rosenfeld

Banting and Best Department of Medical Research, University of Toronto, Toronto 101, Ontario, Canada

Fatty acid synthetase activity was measured in the high-speed supernatant fraction of liver homogenates from rats fed a semisynthetic diet low in lipotropic factors. If choline was omitted from the diet, a significant increase of fatty acid synthetase activity was observed after two feedings of the deficient diet. Compared with controls, the increase of fatty acid synthetase activity was of a magnitude that could account for the amount of triglyceride accumulating in the hepatic floating lipid fraction. Gas-liquid chromatographic analysis of the floating lipid triglycerides showed an increased content of palmitic acid due to choline deficiency; this increase could be predicted from the increased fatty acid synthetase activity and its known characteristic yield of palmitic acid.

Supplementary key words liver • floating lipid triglycerides • palmitic acid

Submitted on November 17, 1972
Revised on March 8, 1973
Accepted on April 19, 1973

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