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Journal of Lipid Research, Vol. 14, 688-691, November 1973
Copyright © 1973 by Lipid Research, Inc.

Lack of effect of chronic nicotine administration on fatty acid distribution in the liver, testis, and adipose tissue of male Fischer-344 rats

R. G. Brindis , B. J. Petersen , J. H. Thompson , and R. B. Alfin-Slater

Departments of Public Health and of Pharmacology and Experimental Therapeutics, University of California School of Medicine, Los Angeles, California 90024

A comparison is made of the percentage compositions of major fatty acids in liver and testis phospholipids, liver and abdominal adipose tissue triglycerides, and liver sterol esters in male Fischer-344 rats administered a physiological saline control or a "smoking" dose of nicotine (1000 µg base/kg/day, subcutaneously) for 2 or 22 months. Results indicate that there is no major trend, or significant difference, between nicotine- or saline-treated rats with respect to major fatty acid distribution. Some differences in fatty acid distribution in the various lipid fractions were found between young and old rats.

Supplementary key words aging • fatty acids • phospholipids • triglycerides • sterol esters

Submitted on January 18, 1973
Revised on April 23, 1973
Accepted on August 9, 1973

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