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Journal of Lipid Research, Vol. 15, 20-25, January 1974
Copyright © 1974 by Lipid Research, Inc.

Mevalonate metabolism by renal tissue in vitro

Philip Raskin and Marvin D. Siperstein

University of Texas Health Sciences Center at Dallas, Dallas, Texas 75235

Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid. Kidneys, however, convert mevalonic acid primarily to the precursors of cholesterol, squalene and lanosterol, rather than to cholesterol. This study was designed to define the specific tissue site within the kidney responsible for mevalonic acid metabolism. Tissue slices from rat and dog renal cortex and medulla and glomeruli and tubules were isolated, and the incorporation of ¹⁴C-labeled mevalonic acid into the nonsaponifiable lipids squalene, lanosterol, and cholesterol was determined in these tissues. The results demonstrate that the renal cortex is the primary site of mevalonic acid metabolism within the kidney and that the glomerulus is responsible for 95% of the mevalonic acid metabolized by the renal cortex. As was the case for the whole kidney, the major metabolites of mevalonate in the glomeruli are squalene and lanosterol.

Supplementary key words glomeruli • tubules • squalene • lanosterol • cholesterol • renal cortex • renal medulla

Submitted on January 27, 1972
Revised on April 2, 1973
Accepted on September 4, 1973

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