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Journal of Lipid Research, Vol. 15, 39-43, January 1974
Copyright © 1974 by Lipid Research, Inc.

Long-chain cyclic acetals of glycerol: metabolism of the stereomeric 1,3-dioxanes and 1,3-dioxolanes in myelinating rat brain

K. L. Su , W. J. Baumann , T. H. Madson , and H. H. O. Schmid

University of Minnesota, The Hormel Institute, Austin, Minnesota 55912

The metabolism of the stereomeric cyclic glycerol acetals of [1-¹⁴C]hexadecanal was studied in myelinating rat brain. It was found that the four isomers, cis- and trans-2-pentadecyl-5-hydroxy-1,3-dioxanes and cis- and trans-2-pentadecyl-4-hydroxymethyl-1,3-dioxolanes, were utilized by the tissue at different rates. The acetals were primarily metabolized via a ring-opening mechanism leading to palmitic acid, some of which was subsequently elongated-desaturated. Only the five-membered ring isomers were incorporated as intact acetals into both neutral and polar brain lipids.

Supplementary key words 2-pentadecyl-5-hydroxy-1,3-dioxane • 2-pentadecyl-4-hydroxymethyl-1,3-dioxolane • enzymic acetal cleavage

Submitted on April 16, 1973
Accepted on August 28, 1973

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