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Journal of Lipid Research, Vol. 15, 84-88, January 1974
Copyright © 1974 by Lipid Research, Inc.

Acceleration of hepatic sterol synthesis after a single dose of the porphyrogenic chemical allylisopropylacetamide

Luigi Taddeini , Ivan Frantz Jr. , and Ajit Sanghvi

Departments of Medicine, St. Paul Ramsey Hospital and University of Minnesota Hospitals, University of Minnesota Medical School, Minneapolis, Minnesota 55455, and Division of Clinical Chemistry, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennyslvania 15213

Hepatic sterol synthesis is accelerated in animals after a single dose of allylisopropylacetamide, a chemical known to be porphyrogenic. Evidence is provided to show that enhanced sterol biosynthesis is due to an increased formation of mevalonic acid, indicating that the primary site of action of the chemical is on one or more steps in the pathway from acetate to mevalonate.

Supplementary key words digitonin-precipitable sterols • porphyria

Submitted on April 4, 1973
Accepted on October 4, 1973

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