Journal of Lipid Research, Vol. 15, 89-93, January 1974
Copyright © 1974 by Lipid Research, Inc.
Changes of gangliosides and other lipids in skeletal muscle from rabbits with experimental dystrophy
I. Albarracín , F. E. Lassaga , and R. Caputto
Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Córdoba, Argentina
Comparison of the skeletal muscles from vitamin E-deficient and control rabbits showed that the muscles from the deficient animals had lower contents of protein and glycogen but more water and lipid. Increases of individual lipids per unit weight of muscle from deficient animals compared with those from control animals were 2.2-fold for gangliosides, 2.18-fold for cholesterol, 1.74-fold for sulfatides, and 1.45-fold for neutral glycosylceramides. Total phospholipids did not change; this was the result of an increase in sphingomyelin (1.47-fold) and a decrease of phosphatidylcholine to 83% of the control, while the other fractions remained unchanged. When the measurements were referred to total muscle, the contents of cholesterol, gangliosides, sulfatides, neutral glycosylceramides, and sphingomyelin in muscle from vitamin E-deficient rabbits were also above those of the control rabbits, and only the phoshatidylcholine content was decreased. It was not possible to determine whether the alteration of lipid content preceded or followed the onset of signs of muscular dystrophy.
Supplementary key words vitamin E deficiency • protein • glycogen • cholesterol • gangliosides • neutral glycosylceramides • sulfatides • phospholipids • phosphatidylcholine • sphingomyelin
Submitted on January 12, 1973
Accepted on September 12, 1973
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