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Journal of Lipid Research, Vol. 15, 352-355, July 1974
Copyright © 1974 by Lipid Research, Inc.

Determination of clofibrate in biological fluids by thin-layer and gas-liquid chromatography

A. Sedaghat , H. Nakamura , and E. H. Ahrens Jr.

The Rockefeller University, New York 10021

A specific and sensitive method is described for the detection of clofibrate in biological fluids. The drug is separated from associated fatty acids by thin-layer chromatography and the methyl ester is quantified by gas-liquid chromatography. Recovery is excellent, and any small losses are corrected with an internal recovery standard. Although more time-consuming than other available techniques, the method offers advantages for accurate studies of clofibrate metabolism.

Supplementary key words p-chlorophenoxyisobutyric acid • internal standards • tritiated clofibrate

Submitted on November 19, 1973
Accepted on February 28, 1974

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