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Journal of Lipid Research, Vol. 15, 457-464, September 1974
Copyright © 1974 by Lipid Research, Inc.

Characterization of the plasma lipoproteins of the genetically obese hyperlipoproteinemic Zucker fatty rat

Gustav Schonfeld , Cynthia Felski , and Mary Ann Howald

Lipid Research Center, Departments of Preventive Medicine and Medicine, Washington University School of Medicine, St. Louis, Missouri 63110

The plasma lipoproteins of the Zucker fatty rat were characterized with respect to lipid and apoprotein composition, and results were compared with those obtained from lean controls. Information on apoproteins was obtained from gel filtration experiments and electrophoresis on polyacrylamide gels. Very low density lipoproteins (VLDL) were increased several-fold in fatties, and 78% of their mass was triglycerides compared with 60% in the controls. Low density (LDL) and high density (HDL) lipoproteins were increased by a factor of 2, although their compositions were similar to those of the controls. Levels of apoVLDL, apoLDL, and apoHDL were five, two and two times higher, respectively, in the fatties, and the two most rapidly moving subunit peptides on polyacrylamide gels were disproportionately elevated in the apoproteins. The slower of these two bands was present in relatively greater amounts than the faster one in fatties. If the slower peptide is an activator of lipoprotein lipase, analogous to the comparable subunit peptides of human apolipoproteins, plasmas of fatties could contain up to 10 times more lipase activator activity than control plasma. This finding, and the fact that adipose tissue lipoprotein lipase activity of fatties was about 150% of controls, suggests that fatties have increased capacities for VLDL catabolism. We have previously shown that hepatic VLDL secretory rates are higher than normal in these animals. The increased capacity for catabolism may be a response to the altered secretory rates.

Supplementary key words apolipoproteins • lipoprotein lipase

Submitted on October 18, 1973
Revised on February 25, 1974
Accepted on April 15, 1974

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