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Journal of Lipid Research, Vol. 15, 551-556, November 1974
Copyright © 1974 by Lipid Research, Inc.

Subcellular localization of hexadecanedioic acid activation in human liver

Jon Elling Pettersen and Magne Aas

Institute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Oslo, Norway

The activation of hexadecanedioic acid has been studied in subcellular fractions of human liver. The activation capacity in a total homogenate of human liver was found to be 0.5 µmole/min/g wet wt of tissue, about 10% of that for palmitic acid. Hexadecanedioic acid was activated by the mitochondrial and microsomal fractions. The mitochondrial enzyme is probably localized outside the inner mitochondrial compartment. The subcellular distribution of the hexadecanedioic acid activation was almost identical with the distribution of palmitic acid activation. Hexadecanedioic and palmitic acids seemed to compete for the same enzyme.

Supplementary key words acyl CoA synthetase • hexadecanoyl CoA:carnitine O-hexadecanoyltransferase • tissue fractionation

Submitted on October 19, 1973
Revised on March 29, 1974
Accepted on May 30, 1974


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