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Journal of Lipid Research, Vol. 15, 574-579, November 1974
Copyright © 1974 by Lipid Research, Inc.

Steroid balance and tissue cholesterol accumulation in germfree and conventional rats fed diets containing saturated and polyunsaturated fats

Thomas F. Kellogg

Department of Biochemistry, Mississippi Agricultural and Forestry Experiment Station, Mississippi State University, Mississippi State, Mississippi 39762

Steroid balance studies were conducted on 24 conventional and 12 germfree male rats, 90-120 days old, fed diets containing either 20% safflower or 20% coconut oil. Both germfree and conventional rats fed the safflower oil diets had significantly lower serum cholesterol levels and significantly higher liver cholesterol levels than did the rats fed coconut oil. No significant differences in total fecal neutral sterols, coprostanol, ⁷-cholestenol, or total fecal bile acid excretion were seen between dietary groups of rats of either status. There was no evidence of qualitative differences in fecal bile acid excretion as a function of diet. The increased liver cholesterol was in the ester form, with cholesteryl linoleate the largest single component. There was no significant difference in the cholesterol content of the skin, muscle, adipose tissue, or gastrointestinal tract. The significance of a large increase in liver cholesteryl ester, lowered serum cholesterol, and no change in steroid excretion is discussed.

Supplementary key words bile acids • coprostanol • ⁷-cholestenol • cholesteryl esters • cholesteryl linoleate • intestinal microflora • fecal steroids

Submitted on January 9, 1974
Revised on June 3, 1974
Accepted on July 24, 1974

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