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Journal of Lipid Research, Vol. 15, 593-601, November 1974
Copyright © 1974 by Lipid Research, Inc.

Influx of cholesterol into plasma in rabbits with fasting hyperbetalipoproteinemia

H. C. Klauda and D. B. Zilversmit

Division of Nutritional Sciences and Section of Biochemistry, Molecular and Cell Biology, Division of Biological Sciences, Cornell University, Ithaca, New York 14850

New Zealand white rabbits exhibited as much as a threefold increase in plasma cholesterol but no change in hepatic cholesterol when fasted for 7-9 days. Agarose electrophoresis and ultracentrifugation of plasma samples showed that only low density lipoprotein increased during fasting. Fasting changed the composition of the low density lipoprotein by increasing the percentage of cholesterol and decreasing the percentage of triglyceride while protein and phospholipid remained the same. Rates of cholesterol secretion into plasma, measured by Triton WR 1339 injection, and rates of plasma cholesteryl ester synthesis, determined by [2-14C]mevalonate injection, were similar for fed and fasted rabbits. These findings suggest that fasting hypercholesterolemia in rabbits did not result from increased production of low density lipoproteins. Triton WR 1339 was shown to inhibit plasma cholesterol esterification in vitro.

Supplementary key words Triton WR 1339 • mevalonate • lipoprotein composition • cholesterol esterification • low density lipoprotein

Submitted on February 8, 1974
Accepted on July 25, 1974


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