Journal of Lipid Research, Vol 16, 258-263, Copyright © 1975 by Lipid Research, Inc.
Cholesterol catabolism in the rabbit in fasted and fed states
HC Klauda and DB Zilversmit
Urinary and fecal endogenous steroid excretion of fed or fasted New Zealand
white rabbits was determined by the isotopic steady state method after
subcutaneous implantation of radioactive cholesterol. While plasma
cholesterol was increasing during a 9-day fast, fecal steroid excretion
decreased to 10% of the excretion rates in the fed state. Refeeding the
fasted rabbits led to a decrease in plasma cholesterol and an increase in
fecal endogenous steroid excretion. Urinary steroid excretion, which
represented 18% of total endogenous steroid excretion for fed animals,
decreased during fasting and increased during refeeding, but these changes
were relatively small. The small intestine, cecum, and colon of fed or
fasted rabbits had similar endogenous steroid was acidic steroid. During
attempts to alter the circulating bile acid concentration by supplying
deoxycholate (200 mg/day) to fed rabbits or cholestyramine (2 g/day) to
fasted rabbits, plasma cholesterol concentration did not change to the same
extent as during fasting or refeeding, respectively. The decreased
cholesterol catabolism and the hypercholesterolemia that are seen in the
fasting rabbit may result from decreased clearance of plasma cholesterol.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
