J. Lipid Res.
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Journal of Lipid Research, Vol 16, 287-292, Copyright © 1975 by Lipid Research, Inc.

ARTICLES

Binding of bile salts to pancreatic colipase and lipase

B Borgstrom and J Donner

The binding of conjugated bile salts to pancreatic colipase and lipase has been studied by equilibrium dialysis and gel filtration. The results indicate that at physiological ionic strength and pH, conjugated bile salts bind as micelles to colipase: 12-15 moles/mole of colipase for the dihydroxy conjugates and 2-4 for the trihydroxy conjugates. No binding of bile salt takes place from monomeric solutions. Under the same experimental conditions, only 1-2 moles of conjugated dihydroxy bile salts bind to pancreatic lipase.
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This article has been cited by other articles:


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