Journal of Lipid Research, Vol 16, 324-331, Copyright © 1975 by Lipid Research, Inc.
Lipogenesis in rabbit adipose tissue
S Smith
Previous reports that rabbit adipose tissue does not synthesize fatty acids
at significant rates led us to study in detail the pathways of lipogenesis
and glyceroneogenesis in this tissue. We found that rabbit adipose tissue
has a low capacity for denovo fatty acid synthesis from glucose but a high
capacity for synthesis from pyruvate and acetate. The tissue can also
convert pyruvate to glyceride-glycerol via the dicarboxylic acid shuttle
and gluconeogenic pathways. Experiments with hydroxycitrate, a potent
inhibitor of citrate cleavage enzyme, demonstrated that this is an
obligatory enzyme in lipogenesis from pyruvate. The lipogenic system of
rabbit adipose tissue resembles that of a ruminant in that it is adapted to
utilize acetate rather than glucose. However, in contrast to ruminant
tissues, the limited ability to convert glucose to fatty acid results not
from a deficiency in the enzymes concerned with the transport of acetyl
units out of the mitochondria but from a block prior to the level of
pyruvate, most likely at the hexokinase and pyruvate kinase reactions.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
