Journal of Lipid Research, Vol 16, 386-391, Copyright © 1975 by Lipid Research, Inc.
Tocopherol in human platelets
A Nordoy and E Strom
A spectrophotometric method was used to determine the total tocopherol
levels in platelets, plasma, and erythrocytes from human subjects. The
platelets contained about three times as much total tocopherol per cell as
erythrocytes. This difference was not related to the content of
polyunsaturated fatty acids in platelets and erythrocytes. In vitro
incubation resulted in significant uptake of tocopherol by plasma and RBC,
whereas no uptake was observed into platelets. A 3-month period of
tocopherol treatment increased the level of tocopherol in plasma and
erythrocytes, whereas the platelet level was unchanged. Tocopherol
treatment did not interfere with platelet function or platelet lipid
metabolism. The tocopherol fractions of platelets, red cells, and plasma
were similar, and alpha-tocopherol was the main fraction.
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