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Journal of Lipid Research, Vol 17, 1-6, Copyright © 1976 by Lipid Research, Inc.

ARTICLES

11, 15, 19-trihydroxy-9-ketoprost-13-enoic acid and 11, 15, 19- trihydroxy-9-ketoprosta-5, 13-dienoic acid in human seminal fluid

HT Jonsson Jr, BS Middleditch, MA Schexnayder and DM Desiderio

Two novel prostaglandins (PG) have been found in human seminal fluid which had been frozen immediately after collection. They were characterized by combined gas-liquid chromatography-mass spectrometry of various derivatives as 19-hydroxy prostaglandin E1 (11, 15, 19- trihydroxy-9-ketoprost-13-enoic acid) and 19-hydroxy prostaglandin E2 (11, 15, 19-trihydroxy-9-ketoprosta-5, 13-dienoic acid). They were present in three to five times the quantity of prostaglandins E1 and E2. Incubation of seminal fluid for 3 hr at 25 degrees C reduced levels of 190H-PGEs2.5-fold and PGE22-fold, while increasing levels of PGAs and PGBs 2-fold. No 190H PGA or 190H PGB was detected in extracts of unincubated fluid. The PGAs, PGBs and their 19-hydroxy analogs are probably artifacts arising metabolically or as a result of classical isolation techniques.
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