HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Borgstrom, B. Articles by Donner, J. Search for Related Content PubMed PubMed Citation Articles by Borgstrom, B. Articles by Donner, J. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 17, 491-497, Copyright © 1976 by Lipid Research, Inc.

ARTICLES

Interactions of pancreatic lipase with bile salts and dodecyl sulfate

B Borgstrom and J Donner

Sodium dodecyl sulfate (SDS) binds to pancreatic lipase in a cooperative manner up to about 200 moles/mole of protein. This binding in a rapid and irreversible inactivation of lipase. Bile salts under certain conditions prevent SDS inactivation of lipase when both detergents are present together. Under these conditions bile salts also prevent the binding of SDS to lipase. This effect is parallel to and probably mediated by a decrease in the SDS monomer concentration as the result of the formation of mixed bile salt-SDS micelles.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?