Journal of Lipid Research, Vol 17, 527-535, Copyright © 1976 by Lipid Research, Inc.
Equally rapid activation of lipogenesis in nibbling and gorging mice
N Baker, DL Palmquist and DB Learn
Minimal average rates of exogenous glucose-C-conversion to whole body,
total lipid fatty acids were measured in nibbling and gorging mice. Gorgers
trained to eat 1 meal/day (8-10 am) were fasted 22-24 hr and given
[14C]glucose with pure glucose, 30% glucose in water, or a 58% glucose,
fat-free diet. Conversion of glucose-C to total lipid fatty acids increased
from 0.6 (fasted) to approximately 20 mug/min/20 g body weight during 40
min after glucose feeding using each test meal. Dietary amino acids were
not required for activation of lipogenesis in gorgers. Exogenous glucose-C
was incorporated into fatty acids as fast in nibbling mice as in gorgers.
This was true after varying all of the following conditions: training
period, number of meals gorged, previous fasting time, and diet
composition. The total rate of fatty acid synthesis from body glucose-C
during absorption of a glucose load was also estimated in absorption of a
glucose load was also estimated in previously fasted nibbling and gorging
mice. These estimates were based on composite, serial measurement of both
plasma glucose specific activities and 14C-labeled fatty acids. The total
rate of fatty acid synthesis from both exogenous and endogenous glucose-C
was only 15% higher than the rate from exogenous glucose-C between 10 and
40 min. No significant differences between nibblers and gorgers were found.
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