Journal of Lipid Research, Vol 17, 600-604, Copyright © 1976 by Lipid Research, Inc.
Circadian distribution of bile acid in the enterohepatic circulatory system in hamsters
KJ Ho
The distribution of bile acid in the enterohepatic circulatory system at
different times of the day was determined in 48 hamsters exposed to a rigid
light schedule (6 AM to 6 PM) and fed, ad libitum, for 4 weeks. In each
portion of the enterohepatic circulatory system, the relative amount of
bile acid was determined 24 hours after an intraperitoneal administration
of [3H]taurocholic acid by comparing the radioactivity recovered from that
portion with the total radioactivity remaining in the entire system. A
circadian fluctuation of the relative bile acid content (percent of total)
was observed in serum, liver, gallbladder, and intestinal contents. The
patterns of such rhythmic change varied in various segments of the
intestinal tract but correlated well with the time sequence of the movement
of bowel content. Rhythms in the serum and liver were intimately related to
the intestinal absorption of bile acid. Due to its small capacity, the
gallbladder played only a minor role in the regulation of such a rhythm.
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