HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cohen, B. I. Articles by Mosbach, E. H. Search for Related Content PubMed PubMed Citation Articles by Cohen, B. I. Articles by Mosbach, E. H. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 18, 223-231, Copyright © 1977 by Lipid Research, Inc.

ARTICLES

Sterol metabolism studies in the rat. Effects of primary bile acids (sodium taurochenodeoxycholate and sodium taurocholate) on sterol metabolism

BI Cohen, RF Raicht and EH Mosbach

Sterol metabolism studies using a combination of isotopic and chromatographic procedures were carried out in rats fed either a low- cholesterol stock diet or a stock diet containing 0.1% cholesterol. The primary bile acids, sodium taurochenodeoxycholate and sodium taurocholate, were added to the stock diets at a level of 0.5%, as required. Feeding sodium taurochenodeoxycholate and sodium taurocholate led to a decrease in acidic steroid synthesis, cholesterol turnover, and cholesterol balance, compared to controls. Sodium taurochenodeoxycholate feeding did not influence cholesterol absorption, but rats fed sodium taurocholate showed a twofold increase in cholesterol absorption as well as an accumulation of cholesterol in the liver. Rats receiving diets containing sodium taurochenodeoxycholate or sodium taurocholate plus cholesterol (0.1%) showed decreased acidic steroid synthesis, cholesterol turnover, and cholesterol balance, compared to the corresponding controls (Group 2, high cholesterol diet). Significantly larger amounts of cholesterol were absorbed in the taurocholate group (34.1 mg/day); these animals increased their concentrations of cholesterol in liver and plasma. The rats fed taurocholate plus 0.1% cholesterol differed from those fed taurochenodeoxycholate plus 0.1% cholesterol in the following respects: a) increased cholesterol absorption (35%), and b) accumulation of cholesterol in liver and plasma.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Mataki, B. C. Magnier, S. M. Houten, J.-S. Annicotte, C. Argmann, C. Thomas, H. Overmars, W. Kulik, D. Metzger, J. Auwerx, et al. Compromised Intestinal Lipid Absorption in Mice with a Liver-Specific Deficiency of Liver Receptor Homolog 1 Mol. Cell. Biol., December 1, 2007; 27(23): 8330 - 8339. [Abstract] [Full Text] [PDF]

				D. Q.-H. Wang, S. Tazuma, D. E. Cohen, and M. C. Carey Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G494 - G502. [Abstract] [Full Text] [PDF]

				J. D. Horton, J. A. Cuthbert, and D. K. Spady Regulation of Hepatic 7alpha-Hydroxylase Expression and Response to Dietary Cholesterol in the Rat and Hamster J. Biol. Chem., March 10, 1995; 270(10): 5381 - 5387. [Abstract] [Full Text] [PDF]