Journal of Lipid Research, Vol 19, 3-11, Copyright © 1978 by Lipid Research, Inc.
The participation of ethyl 4-benzyloxybenzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism
R Fears, KH Baggaley, R Alexander, B Morgan and RM Hindley
Investigation into the mechanism of action of BRL 10894 (ethyl 4-
benzyloxybenzoate), a compound possessing hypolipidemic activity in the
rat, disclosed participation in glycerolipid metabolism. In the presence of
BRL 10894, an abnormal metabolite was synthesized in vitro using liver
slices or rings of small intestine with glycerol, palmitate, or monoolein
as substrate, and using adipose tissue with pyruvate as substrate. Esters
related chemically to BRL 10894 and other pharmacologically active acids
(e.g., ibuprofen) also produced abnormal metabolites in vitro. With BRL
10894 in the diet, a similar metabolite was produced in vivo in rats and
accumulated in adipose tissue. Chemical characterization of the material
synthesized in vivo showed that the metabolite was a triglyceride in which
one fatty acid moiety was substituted by the acid of BRL 10894. Additional
proof of this structure was obtained by comparison with reference material
synthesized in our laboratories. The study of the initimate involvement of
exogenous acids in glycerolipid turnover is of value in the
characterization of pharmacologically important acids and may be of use in
achieving a greater understanding of certain aspects of lipid metabolism.
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