Journal of Lipid Research, Vol 19, 57-64, Copyright © 1978 by Lipid Research, Inc.
Ehrlich ascites tumor cell surface membranes: an abnormality in ether lipid content
SJ Friedberg and M Halpert
Most mammalian neoplasms have a defect in ether lipid content manifested by
the presence of abnormally large quantities of 0-alkyl glyceryl ethers, in
contrast to normal tissues in which the alk-1-enyl structure predominates.
These lipids are for the most part structural. The manner in which tumor
cell plasma membranes differ from normal may be important, and it has been
hitherto unclear whether or not the 0- alkyl lipid abnormality of neoplasms
includes the plasma membrane. The present investigation reveals that
0-alkyl lipids are present in the membranes of Ehrlich ascites tumor cells
isolated by several different methods. The amount of 0-alkyl lipid, on a
weight basis, represents 1-3 percent of the total phospholipids and 1-4
percent of the total aliphatic lipid. These quantities are the same as or
greater than the amount of 0-alkyl lipid found in microsomes, mitochondria,
and whole cell homogenate. As is generally the case for intact neoplastic
tissues, the quantity of 0-alkyl lipids of Ehrlich ascites tumor plasma
membrane is greater than the amount of alk-1-enyl lipids.
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