J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Poorthuis, B. J.
Right arrow Articles by Hostetler, K. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Poorthuis, B. J.
Right arrow Articles by Hostetler, K. Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol 19, 309-315, Copyright © 1978 by Lipid Research, Inc.

ARTICLES

Conversion of diphosphatidylglycerol to bis(monoacylglyceryl)phosphate by lysosomes

BJ Poorthuis and KY Hostetler

Diphosphatidyl[1',2',3'-14C]glycerol (cardiolipin) is converted to bis(monoacylglyceryl)phosphate when incubated in vitro with rat lysosomes at pH 4.4. The stereochemical configuration of the product is unknown. This reaction probably takes place via lysophosphatidylglycerol, one of the major products of diphosphatidylglycerol hydrolysis by lysosomes. Phosphatidyl[1',2',3'- 14C]glycerol was introduced into mitochondrial membranes by incubating mitochondria with [U-14C]sn-glycerol-3-phosphate and cytidine diphosphate diacylglycerol. Membrane-bound phosphatidyl[1',2',3'- 14C]glycerol is also converted to bis(monoacylglycerol)phosphate when incubated with lysosomes in a reaction that is dependent on the concentration of lysosomal protein and on incubation time. These results support our previous proposal (Poorthuis, B. J. H. M., and K. Y. Hostetler, 1976. J. Biol. Chem. 251: 4596-4602) that bis(monoacylglyceryl)phosphate formation may require the interaction of lysosomes with other membranes that contain the substrates for the reaction. The stereochemistry of bis(monoacylglyceryl)phosphate biosynthesis is discussed.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
F. Hullin-Matsuda, K. Kawasaki, I. Delton-Vandenbroucke, Y. Xu, M. Nishijima, M. Lagarde, M. Schlame, and T. Kobayashi
De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate
J. Lipid Res., September 1, 2007; 48(9): 1997 - 2008.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1978 by the American Society for Biochemistry and Molecular Biology.