Journal of Lipid Research, Vol 19, 335-341, Copyright © 1978 by Lipid Research, Inc.
Description of obesity in the PBB/Ld mouse
SU Walkley, CE Hunt, RS Clements and JR Lindsey
A new strain of obese mouse, the PBB/Ld, has been studied in terms of fat
pad cellularity, serum insulin and blood glucose levels, and response to
gold thioglucose injections. Age-matched C57B1/6J mice were used as
controls. Adipocyte size and number in the major fat depots were determined
at various ages from weanling to maturity in the PBB/Ld and C57B1/6J
strains. Results indicated that obesity in the PBB/Ld was due to
hypertrophy of adipocytes in retroperitoneal and subcutaneous fat depots
and to hypertrophy and hyperplasia in the epididymal fat pad. PBB/Ld mice
also developed hyperinsulinemia and hyperglycemia and these findings have
been discussed in terms of the developmental changes in fat pad
cellularity. The injection of gold thioglucose led to increased food intake
in both PBB/Ld and C57B1/6J mice. Hyperphagia was also present in the
PBB/LD control group, but increased efficiency of converting calories to
body weight was not observed in this group when compared to control
C57B1/6J mice. The characteristics of obesity seen in the PBB/Ld mouse are
discussed and comparisons are made to similar studies in other rodent
models of obesity.
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