HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Traber, M. G. Articles by Ostwald, R. Search for Related Content PubMed PubMed Citation Articles by Traber, M. G. Articles by Ostwald, R. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 19, 448-456, May 1978
Copyright © 1978 by Lipid Research, Inc.

Cholesterol absorption and steroid excretion in cholesterol-fed guinea pigs

Maret G. Traber and R. Ostwald

Department of Nutritional Sciences, University of California, Berkeley, CA 94720

Cholesterol absorption was studied in groups of guinea pigs fed diets containing 0, 0.1%, or 1% cholesterol. A similar proportion of tracer cholesterol was absorbed regardless of the cholesterol content of the diet. Furthermore, the proportion of tracer cholesterol absorbed by individual animals did not change when the cholesterol-free diet was changed to one containing 1% cholesterol.

Cholesterol absorption was also measured in hyporesponding guinea pigs. These guinea pigs had been fed 1% cholesterol-containing diets for nearly a year with minimal pathological effects. These hyporesponders had a decreased intestinal transit time, which enabled them to decrease the fractional absorption of cholesterol below the levels seen in the controls, and to absorb less cholesterol/kg body weight than the hyperresponders.

Excretion of total and of neutral steroids was measured in guinea pigs fed 0 or 1% cholesterol-containing diets. The 1% cholesterol-fed guinea pigs increased the excretion of steroids 3-fold over control levels. However, they absorbed more dietary cholesterol than they excreted in any form. It seems, therefore, that a major cause of the cholesterol pool expansion in the guinea pig is its inability to limit absorption of dietary cholesterol in conjunction with its inability to sufficiently increase excretion of steroids.

Supplementary key words cholesterol pool • cholesterol balance • cholesterol metabolism • bile acid excretion • plant sterols • aging • cholesterol hyporespondence

Submitted on July 25, 1977
Accepted on November 28, 1977

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L.-P. Duan, H. H. Wang, A. Ohashi, and D. Q.-H. Wang Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G269 - G276. [Abstract] [Full Text] [PDF]

				H. H. Wang, N. H. Afdhal, S. J. Gendler, and D. Q.-H. Wang Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G547 - G554. [Abstract] [Full Text] [PDF]

				D. Q.-H. Wang, S. Tazuma, D. E. Cohen, and M. C. Carey Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G494 - G502. [Abstract] [Full Text] [PDF]

				D. Q-H. Wang and M. C. Carey Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies J. Lipid Res., May 1, 2003; 44(5): 1042 - 1059. [Abstract] [Full Text] [PDF]

				D. Q-H. Wang Aging per se is an independent risk factor for cholesterol gallstone formation in gallstone susceptible mice J. Lipid Res., November 1, 2002; 43(11): 1950 - 1959. [Abstract] [Full Text] [PDF]

				D. Q-H. Wang, B. Paigen, and M. C. Carey Genetic factors at the enterocyte level account for variations in intestinal cholesterol absorption efficiency among inbred strains of mice J. Lipid Res., November 1, 2001; 42(11): 1820 - 1830. [Abstract] [Full Text] [PDF]

				S. R. Chowdhury, J. K. Mishra, and C. K. Das Shrinkability and Microstructural Properties of Composites Based on Low-Density Polyethylene (LDPE) and Polyurethane (PU) Rubber Journal of Thermoplastic Composite Materials, September 1, 2000; 13(5): 400 - 416. [Abstract] [PDF]