Journal of Lipid Research, Vol 19, 763-770, Copyright © 1978 by Lipid Research, Inc.

ARTICLES

Hepatic lipid metabolism. Age-related changes in triglyceride metabolism

SC Jamdar, M Moon, S Bow and HJ Fallon

Age-related changes in hepatic triglyceride formation have been described in developing rats. Triglyceride formation was measured in vitro in the presence of [14C]glycerol-3-phosphate, palmitate, ATP, CoA, and Mg2+ by using liver homogenates and microsomal fractions derived from various age groups of animals. Triglyceride formation was most active in one-day-old rats and then decrease with age. The increase in triglyceride formation following birth was prevented by the administration of puromycin or by denying suckling. In addition, changes in plasma and hepatic triglyceride concentrations, were also determined as functions of age. These studies suggest that the age of the animal significantly influences triglyceride metabolism.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S.-H. Chon, Y. X. Zhou, J. L. Dixon, and J. Storch Intestinal Monoacylglycerol Metabolism: DEVELOPMENTAL AND NUTRITIONAL REGULATION OF MONOACYLGLYCEROL LIPASE AND MONOACYLGLYCEROL ACYLTRANSFERASE J. Biol. Chem., November 16, 2007; 282(46): 33346 - 33357. [Abstract] [Full Text] [PDF]

				I. J. Waterman, N. T. Price, and V. A. Zammit Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes J. Lipid Res., September 1, 2002; 43(9): 1555 - 1562. [Abstract] [Full Text] [PDF]