Journal of Lipid Research, Vol 19, 856-862, Copyright © 1978 by Lipid Research, Inc.
The extracorporeal bile duct: a new model for determination of bile flow and bile composition in the intact rat
EE Weis and CA Barth
A new model is described which allows measurement of bile flow and sampling
of bile in the intact rat with a physiologically functioning sphincter of
Oddi. A number of metabolic parameters have been followed to show that
animals with such an "extracorporeal bile duct" (EBD) behave as intact
controls. Especially, there was no difference in the increase in body
weight or hepatic fatty acid and cholesterol synthesis between EBD animals
and intact controls. The amount of bile salts circulating through the
biliary tract amounted to 30.5+/-1.5mumol . 100 g body wt-1 . hr-1, when
diurnal variations were averaged. Animals adapted to a restricted feeding
regimen showed a significant increase of bile flow and of biliary bile salt
and cholesterol excretion during feeding (10AM-3 PM); these parameters
reached their maximum 3 hours after onset of food intake.
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