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Journal of Lipid Research, Vol 19, 1004-1016, Copyright © 1978 by Lipid Research, Inc.
B Angelin, K Einarsson, K Hellstrom and B Leijd
Bile acid and plasma endogenous triglyceride kinetics were determined under
standardized dietary conditions in 47 hyperlipidemic subjects with the aid
of [14C]cholic acid, [14C]chenodeoxycholic acid, and [3H]glycerol,
respectively. On the basis of their lipoprotein pattern the patients were
separated into three groups characterized by hyperlipoproteinemia (HLP)
type IIa (n = 19), type IIb (n = 6), and type IV (n = 22). In keeping with
previous reports from this laboratory the total bile acid formation reports
from this laboratory the total bile acid formation in HLP type IV (19.5 +/-
2.2) mumol kg-1d-1, mean +/- SEM) exceeded that encountered in type IIa
(10.7 +/- 0.9 mumol kg- 1d-1, P less than 0.005). This difference was
mainly due to an increased synthesis of cholic acid in type IV HLP (12.7
+/- 1.7 mumol kg-1d-1 vs. 6.1 +/- 0.5 mumol kg-1d-1, P less than 0.005).
Bile acid formation in type IIb HLP was essentially within the limits
recorded for type IIa. Apparent plasma triglyceride formation (as
calculated from the 10-hr radioactivity decay curve) averaged 10.5 +/- 0.7
mumol kg-1hr-1 in type IIa HLP and was significantly higher in type IIb
(20.7 +/- 1.9 mumol kg-1hr-1, P less than 0.001) and in type IV (22.1 +/-
1.4 mumol kg-1hr-1, P less than 0.001). The apparent fractional turnover
rate of plasma triglyceride in type IV HLP (0.147 +/- 0.011 hr-1) was lower
than that encountered in type IIa (0.188 +/- 0.008, P less than 0.01) and
in type IIb (0.177 +/- 0.011 hr-1). The apparent production of plasma
triglycerides and the formation of cholic acid correlated in type IIa (r =
+0.69, P less than 0.001) and in type IV HLP (r = +0.70, P less than
0.001). A similar pattern was seen for total bile acid formation, while
chenodeoxycholic acid showed a correlation to apparent triglyceride
synthesis only in type IV HLP. It is suggested that an increased formation
of plasma triglycerides--monitoring very low density lipoprotein
synthesis--is linked to an enhanced degradation of cholesterol to bile
acids and that there is an integrated regulation of the metabolism of these
two parameters.
ARTICLES
Bile acid kinetics in relation to endogenous tryglyceride metabolism in various types of hyperlipoproteinemia
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