Journal of Lipid Research, Vol 19, 978-984, Copyright © 1978 by Lipid Research, Inc.
Endogenously labeled low density lipoprotein triglyceride and apoprotein B kinetics
C Malmendier and M Berman
The kinetics of endogenously labeled low density lipoprotein (LDL)
triglycerides (TG) and apoprotein B (apoB) have been studied in four normal
and in four hyperlipemic subjects using double tracers. Analysis of the
data suggests that most LDL triglycerides turn over about 10 times faster
than apoB (0.003/min vs. 0.0003/min) and that about 10% of the LDL
particles contain most of the TG found with LDL. It is not possible to
determine from the analysis whether each new LDL particle arrives with the
excess TG or whether only a subpopulation of particles contains most of the
TG. The kinetic analysis further suggests that triglyceride-rich LDL
particles do not exchange with an extraplasma compartment as most LDL
particles do, and thus, they behave more like very low density lipoprotein
particles. A compartmental model accounting for both the LDL-TG and
LDL-apoB kinetics is proposed.
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