J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol. 2, 188-190, April 1961
Copyright © 1961 by Lipid Research, Inc.

The in vivo effect of digitoxin on rat heart phosphatides

G. V. Marinetti , K. Temple , and Elmer Stotz

Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester 20, N. Y.

Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin. The increase in specific activity was demonstrated in both lecithin and phosphatidyl ethanolamine. The other heart muscle lipids were not investigated. Glycerol and ethanol, which are constituents of the vehicle in which the digitoxin is dissolved, do not alter the specific activity of the heart muscle phosphatides. The vehicle itself (without digitoxin) has some activity.

Submitted on July 25, 1960


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