J. Lipid Res. Please sign the JLR Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weiss, H.
Right arrow Articles by Titus, E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Weiss, H.
Right arrow Articles by Titus, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 2, 258-262, July 1961
Copyright © 1961 by Lipid Research, Inc.

Effect of mevalonate analogues upon cholesterol biosynthesis

Herbert Weiss , Elliott Schiffmann , and Elwood Titus

Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland

Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Dgr2-3-methyl pentenoic acid > Dgr3-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 µmoles/ml of homogenate. This corresponds to a ratio of 100 µmoles of inhibitor to 1 µmole of substrate.

Submitted on October 28, 1960


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1961 by the American Society for Biochemistry and Molecular Biology.