J. Lipid Res. Acyl Labeled PIP's available August 1, 2008
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Journal of Lipid Research, Vol. 2, 344-349, October 1961
Copyright © 1961 by Lipid Research, Inc.

Cholesterol and mevalonate metabolism: a time course study in vivo

J. C. Elwood and J. T. Van Bruggen

Department of Biochemistry, University of Oregon Medical School, Portland 1, Oregon

Within 30 minutes after injecting dl-mevalonate-2-C14 into young rats, the total body nonsaponifiable fraction contained 47.6% of the biologically active C14-mevalonate. Time course data suggest that at this time utilization of tracer MVA was essentially complete. Urinary radioactivity accounted for slightly more than one-half of the dose. The metabolism of nonsaponifiable fractions of liver and gut may be related by two processes having similar but reciprocal half times. Kidney tissue was found to contain the greater part of the radioactivity previously associated with carcass nonsaponifiable fractions. A small but consistent amount of label was found in the saponifiable fractions.

Submitted on July 25, 1960


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