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Journal of Lipid Research, Vol. 2, 350-356, October 1961
Copyright © 1961 by Lipid Research, Inc.

The effect of dietary fatty acids on coprostanol excretion by the rat

Jean D. Wilson

Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas 35, Texas

By means of gas-liquid chromatographic analysis, coprostanol excretion has been studied in rats fed diets containing either no fat or varying amounts of linoleic acid, palmitic acid, or oleic acid. Coprostanol excretion was accelerated by linoleic acid, and depressed by oleic and palmitic acids. The acceleration of coprostanol formation by linoleic acid was demonstrated to occur in the large intestine. In these experiments cholesterol and coprostanol were the only neutral excretion products of cholesterol-4-C14.

Submitted on February 20, 1961


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