J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol. 2, 396-399, October 1961
Copyright © 1961 by Lipid Research, Inc.

Release of free fatty acids by adipose tissue in vivo

John J. Spitzer and Frank J. Hohenleitner

Department of Physiology, Hahnemann Medical College and Hospital, Philadelphia 2, Pennsylvania

A technique is described to determine changes in plasma FFA on passage through adipose tissue in vivo. The subcutaneous adipose tissue of the abdominal region was shown to be constantly releasing FFA. After the injection of insulin, mobilization of FFA was depressed in normal as well as in diabetic dogs, but seldom was there any evidence of FFA uptake. Lymph infusion from fat-absorbing donors did not seem to influence the release of FFA by adipose tissue in the recipient animals.

Submitted on March 8, 1961


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