HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Witting, L. A. Articles by Horwitt, M. K. Search for Related Content PubMed Articles by Witting, L. A. Articles by Horwitt, M. K. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 2, 412-418, October 1961
Copyright © 1961 by Lipid Research, Inc.

Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver

L. A. Witting , C. C. Harvey , B. Century , and M. K. Horwitt

L. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois, and Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, Illinois

The fatty acid composition of erythrocyte and liver mitochondrial lipids was readily and drastically altered by varying the fatty acid content of the diet. Nonessential polyunsaturated fatty acids were found in these tissues when the tissue level of linoleic acid fell below 10% of the total fatty acids. In essential fatty acid deficiency, two isomeric eicosatrienoic acids appeared, except when the diet supplied other more highly unsaturated nonessential fatty acids. Although brain mitochondrial lipids were relatively less affected by dietary manipulations, their fatty acid compositions could be significantly altered by variations of dietary fat; nonessential polyunsaturated fatty acids from cod liver oil were also incorporated into these lipids. It is postulated that such alterations in the polyunsaturated fatty acid content of phospholipids, other lipid complexes, or both, may be of importance in metabolism.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. K Horwitt Critique of the requirement for vitamin E Am. J. Clinical Nutrition, June 1, 2001; 73(6): 1003 - 1005. [Abstract] [Full Text] [PDF]