Journal of Lipid Research, Vol 20, 183-199, Copyright © 1979 by Lipid Research, Inc.
Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin
MJ Janiak, DM Small and GG Shipley
The ternary phase diagram of cholesteryl myristate--dimyristoyl
lecithin--water has been determined by polarizing light microscopy,
scanning calorimetry, and x-ray diffraction. Hydrated dimyristoyl lecithin
forms a lamellar liquid--crystalline phase (L alpha) at temperatures
greater than 23 degrees C into which limited amounts of cholesteryl
myristate (less than 5 wt. %) can be incorporated. The amount of
cholesterol ester incorporated is dependent upon the degree of hydration of
the L alpha phase. Below 23 degrees C dimyristoyl lecithin forms ordered
hydrocarbon chain structures (L beta' and P beta') which do not
incorporate cholesterol ester. Comparison with other
phospholipid--cholesterol ester--water phase diagrams suggests the
following general principles: i) the incorporation of cholesterol ester
occurs only into liquid crystalling phospholipid bilayers, ii) the extent
of incorporation is temperature-dependent, with increasing amounts of
cholesterol ester being incorporated at higher temperatures, and iii)
unsaturated cholesterol esters induce increased disordering of the
phospholipid bilayers.
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