J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reaven, G. M.
Right arrow Articles by Reaven, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reaven, G. M.
Right arrow Articles by Reaven, E. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 20, 371-378, March 1979
Copyright © 1979 by Lipid Research, Inc.

Characterization of a model of dietary-induced hypertriglyceridemia in young, nonobese rats

Gerald M. Reaven , Tranquilina R. Risser , Y-D. Ida Chen , and Eve P. Reaven

Stanford University School of Medicine and Veterans Administration Hospital, Palo Alto, CA 94304

Healthy, nonobese, young rats developed hypertriglyceridemia (mean triglyceride levels of 250 mg/dl) following consumption of a sucrose-lard diet. The hypertriglyceridemia was apparent three days after start of the diet and persisted throughout the 4-week experimental period. Body weight, liver weight, and serum glucose levels were similar in animals eating either the sucrose-lard diet or standard rat chow. On the other hand, serum free fatty acid levels were slightly increased and serum insulin levels were substantially increased in animals eating the sucrose-lard diet. Determination of very low density lipoprotein turnover revealed that total triglyceride secretion in rats eating the sucrose-lard diet was significantly (P < 0.01) increased over that of rats eating standard chow. Direct measurement of hepatic and intestinal very low density lipoprotein secretion indicated that the observed rise in total triglyceride secretion was secondary to increased secretion of very low density lipoproteins by the liver. Finally, lipoprotein lipase activity of adipose tissue from rats eating the sucrose-lard diet was equal to, or greater than (depending upon sampling time), the activity of the enzyme from adipose tissue of rats eating the control diet. These data indicate that young, nonobese, rats develop hypertriglyceridemia when they ingest a sucrose-lard diet, and that the rise in plasma triglyceride levels results from an increase in hepatic very low density lipoprotein secretion. The dietary-induced hypertriglyceridemia is associated with elevated serum insulin levels, and, as such, may provide a useful animal model to use in studies aimed at defining the pathogenesis of endogenous hypertriglyceridemia in man.—Reaven, G. M., T. R. Risser, Y-D. I. Chen, and E. P. Reaven. Characterization of a model of dietary-induced hypertriglyceridemia in young, nonobese rats.

Supplementary key words endogenous hypertriglyceridemia • sucrose-lard diet • hyperinsulinemia • hepatic VLDL-TG secretion • intestinal VLDL-TG secretion • lipoprotein lipase

Submitted on June 13, 1978
Accepted on August 15, 1978


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. E. Hafidi, I. Perez, J. Zamora, V. Soto, G. Carvajal-Sandoval, and G. Banos
Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1387 - R1393.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Laplante, H. Sell, K. L. MacNaul, D. Richard, J. P. Berger, and Y. Deshaies
PPAR-{gamma} Activation Mediates Adipose Depot-Specific Effects on Gene Expression and Lipoprotein Lipase Activity: Mechanisms for Modulation of Postprandial Lipemia and Differential Adipose Accretion
Diabetes, February 1, 2003; 52(2): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. B. Lingelbach and R. B. McDonald
Description of the Long-Term Lipogenic Effects of Dietary Carbohydrates in Male Fischer 344 Rats
J. Nutr., December 1, 2000; 130(12): 3077 - 3084.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. El Hafidi and G. Banos
In Vivo Plasma Lipid Oxidation in Sugar-Induced Rat Hypertriglyceridemia and Hypertension
Hypertension, September 1, 1997; 30(3): 624 - 628.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Jeppesen, C. B. Hollenbeck, M.-Y. Zhou, A. M. Coulston, C. Jones, Y.-D. I. Chen, and G. M. Reaven
Relation Between Insulin Resistance, Hyperinsulinemia, Postheparin Plasma Lipoprotein Lipase Activity, and Postprandial Lipemia
Arterioscler. Thromb. Vasc. Biol., March 1, 1995; 15(3): 320 - 324.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Picard, A. Boivin, J. Lalonde, and Y. Deshaies
Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet
Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E412 - E418.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1979 by the American Society for Biochemistry and Molecular Biology.