Journal of Lipid Research, Vol. 20, 428-436, May 1979
Copyright © 1979 by Lipid Research, Inc.

Lipid composition of human neural tumors

Allan J. Yates , Diann K. Thompson , Carl P. Boesel , Christine Albrightson , and Ronald W. Hart

Department of Pathology and Department of Radiology, Ohio State University, Columbus OH 43210

Gangliosides, cholesterol, and phospholipids were quantitated in the tissues of 11 human neural tumors and the cells of two gliomas cultured in vitro. All tumor tissues contained higher water concentrations but lower total lipid concentrations than either human grey or white matter. In general they contained less cholesterol, sphingomyelin, and serine glycerophospholipid but more choline glycerophospholipid than white matter. Concentrations of total ganglioside sialic acid were intermediate between grey and white matter. Compared with normal brain, all tumors had greater proportions of the structurally less complex gangliosides and smaller proportions of the more complex gangliosides. This was most marked in the rapidly growing tumors while the better differentiated astrocytomas contained the greatest proportions of complex gangliosides. The cells of the cultured tumors contained amounts of total lipid and total phospholipid similar to their parent tissues. However, the cultures had less cholesterol, sphingomyelin, and total ganglioside than their parent tissues. There were significant amounts of choline and ethanolamine plasmalogens in both cultures and parent tissues. The ganglioside patterns of both cultures were complex but they contained a greater proportion of structurally simpler gangliosides than their parent tissues.—Yates, A. J., D. K. Thompson, C. P. Boesel, C. Albrightson, and R. W. Hart. Lipid composition of human neural tumors.

Supplementary key words ganglioside • phospholipid • plasmalogen • astrocytoma • glioma • neuroblastoma • tissue culture • tumor

Submitted on July 5, 1978
Accepted on November 6, 1978

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