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Journal of Lipid Research, Vol 20, 994-998, Copyright © 1979 by Lipid Research, Inc.

ARTICLES

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl- substituted 15-oxygenated sterols

GJ Schroepfer Jr, EJ Parish, M Tsuda, DL Raulston and AA Kandutsch

Reported herein are the results of investigations of the effects of a number of 14 alpha-alkyl-substituted 15-oxygenated sterols, prepared by chemical synthesis, on sterol biosynthesis and the levels of 3-hydroxy- 3-methylglutaryl CoA reductase activity in L cells and in primary cultures of fetal mouse liver cells grown in serum-free media. Several of the compounds, most notably 14 alpha-ethyl-5 alpha-cholest-7-en-3 beta, 15 alpha-diol and 14 alpha-ethyl-5 alpha-cholest-7-en-15 alpha-ol- 3-one, were found to be extraordinarily potent inhibitors of sterol synthesis in these cells. For example, the latter compound caused a 50% inhibition of the incorporation of labeled acetate into digitonin- precipitable sterols in L cells in culture at a concentration of 6 X 10(-9) M.
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This article has been cited by other articles:

				G. J. Schroepfer Jr. Oxysterols: Modulators of Cholesterol Metabolism and Other Processes Physiol Rev, January 1, 2000; 80(1): 361 - 554. [Abstract] [Full Text] [PDF]