Journal of Lipid Research, Vol 21, 44-52, Copyright © 1980 by Lipid Research, Inc.
Effect of aging and cellularity on lipolysis in isolated mouse fat cells
SR Jolly, YB Lombardo, JJ Lech and LA Menahan
The effects of age and cellularity on lipolysis have been investigated in
isolated epididymal fat cells from both Swiss albino mice and
Sprague-Dawley rats. No significant lipolytic response to glucagon could be
demonstrated with adipocytes from either young or old mice, while glycerol
output was increased by this hormone with fat cells from young rats. Larger
adipocytes from older mice showed significantly greater
isoproterenol-stimulated lipolysis than those from younger animals if the
glycerol output was expressed on a per cell basis. However, the lipolytic
response per cell appeared to be equivalent in young and old rat adipocytes
with either isoproterenol or ACTH-(1-24). In a complete aging study,
relationships between body weight, epididymal fat pad weight and
cellularity were examined covering the life span of the mouse. ACTH-(1-24)-
and dibutyryl cyclic AMP- stimulated lipolysis increased with age and cell
size but fell at senescence when adipocyte size diminished. Although an
effect of aging per se cannot be ruled out with the experimental techniques
used in the present study, a dominant influence of adipocyte size on the
lipolytic process was demonstrated.
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