Journal of Lipid Research, Vol 21, 156-161, Copyright © 1980 by Lipid Research, Inc.
Lipolysis and cyclic AMP response to isoproterenol in diaphragms from control and dystrophic mice
NA Abumrad, HM Tepperman and J Tepperman
A comparison was made of the sensitivity of lipolysis (glycerol and free
fatty acid release) and of cyclic AMP production to the action of
isoproterenol in diaphragms from control and dystrophic Bar Harbor mice at
7 weeks of age. An increased lipolytic response was observed in diaphragms
from dystrophic mice that was more apparent in the males, and was
demonstrable when cyclic AMP was used instead of isoproterenol. The
increased glycerol and free fatty acid release in response to isoproterenol
and cyclic AMP cannot be explained by a higher triglyceride content of
diaphragms from dystrophic mice, because it was found to be similar to that
of controls when it was estimated by biochemical and light microscopic
techniques. The increased lipolytic response was not paralleled by changes
in cyclic AMP levels, which were found to be similar in diaphragms from
control and dystrophic mice, whether in the basal or the stimulated state.
It was concluded that the lipolytic apparatus in muscles from dystrophic
mice shows an increased sensitivity to isoproterenol that seems to be
related to events more intracellular than the cAMP production step.
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