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Journal of Lipid Research, Vol 21, 257-258, Copyright © 1980 by Lipid Research, Inc.


ARTICLES

A simplified procedure for the preparation of 2,3-O-isopropylidene-sn- glycerol from L-arabinose

P Kanda and MA Wells

A new procedure for the preparation of 2,3-O-isopropylidene-sn-glycerol is described. L-arabinose is converted to its 4,5-monoisopropylidene diethyl mercaptal derivative. This compound is then subjected to periodate oxidation and borohydride reduction. Following neutralization, the aceton-glycerol is extracted from the aqueous solution into chloroform. Evaporation of the chloroform and subsequent distillation yielded pure 2,3-O-isopropylidene-sn-glycerol ([alpha]D22 = -14.5 degrees (in substance)) in an overall yield of 15-25%.
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