Journal of Lipid Research, Vol 21, 347-353, Copyright © 1980 by Lipid Research, Inc.
Phospholipid synthesis and exchange between rat liver microsomes and mitochondria in the presence of benzo(a)pyrene
J Baraud and A Maurice
Benzo(a)pyrene injection increased the phospholipid content in membranes of
rat liver mitochondria and microsomes. There was a large relative increase
of phosphatidylcholine, especially in microsomes, as compared with normal
liver. The quantity of phosphatidylethanolamine seemed not be affected and
the other phospholipid classes decreased. In vivo [U-14C]glycerol
incorporation into phospholipids was greater after benzo(a)pyrene
injection, especially into phosphatidylcholine. Liver microsomes derived
from rats injected with [U-14C]glycerol or from liver slices incubated with
the same precursor were incubated with unlabeled mitochondria in the
presence of 105,000 g supernatant fraction; labeled microsomal
phospholipids exchanged to a greater extent in the presence of
benzo(a)pyrene, suggesting either a stimulation of activity of the exchange
proteins, or a relative membrane disorganization facilitating the
phospholipid transfer.
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